Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US10456449B2 · kind B2 · utility
9Cited by
66References
63Claims
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Key dates
| Filing date | Jun 15, 2015 |
| Grant date | Oct 29, 2019 |
| Priority date | — |
| Expiry date | Jul 10, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods of modulating bile acid homeostasis or treating a bile-acid related or associated disorder, comprising using variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), in combination with agents effective in modulating bile acid homeostasis or treating a bile-acid related or associated disorder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.