Substituted amides for treating and preventing cancer

US10457662B2 · kind B2 · utility

Assignees

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US
• The Board of Regents of the University of Texas System · US

Inventors

• Nouri Neamati · Ann Arbor, US
• Jia Zhou · Galveston, US
• Yuting Kuang · Ann Arbor, US
• Na Ye · 安丰镇, CN

Key dates

• Filing date: May 20, 2016
• Grant date: Oct 29, 2019
• Expiry date: May 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to novel small molecule compounds having a quinolin-8-yl-nicotinamide structure (e.g., a compound having Formula I: which are useful in treating, ameliorating, or preventing various forms of cancer (e.g., pancreatic cancer).