Substituted pyrrolo[2,3-b]pyridines as inhibitors of cellular necroptosis
US10457678B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Oct 13, 2016 |
| Grant date | Oct 29, 2019 |
| Priority date | — |
| Expiry date | Oct 13, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to new N1- and N7-substituted sibiriline derivatives of the following general formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as drug, in particular for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising such a compound and processes to prepare such a compound. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.