Patent · US Active

Process for preparing a PARP inhibitor, crystalline forms, and uses thereof

US10457680B2 · kind B2 · utility

2Cited by

3References

23Claims

0Family size

Assignee

BeiGene, Ltd. · KY

Inventors

Hexiang Wang · Beijing, CN
Changyou Zhou · Princeton, US
Bo Ren · Beijing, CN
Xianzhao Kuang · Beijing, CN

Key dates

Filing date	Aug 22, 2016
Grant date	Oct 29, 2019
Priority date	—
Expiry date	Aug 22, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Provided are a process for preparing a Parp1/2 inhibitor, i.e., (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one (hereinafter referred to as Compound A), crystalline forms (poly-morphs) of Compound A or hydrate or solvate thereof, methods for preparing the crystalline forms, and the use thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.