Engineered polypeptides
US10457717B2 · kind B2 · utility
10Cited by
15References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 23, 2018 |
| Grant date | Oct 29, 2019 |
| Priority date | — |
| Expiry date | May 22, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/70
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided herein are polypeptides that bind to a blood-brain barrier (BBB) receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a BBB receptor-expressing cell, e.g., for transport across the BBB. Also provided herein are transferrin receptor (TfR) constructs that comprise a monomeric TfR apical domain or one or more portions of the TfR apical domain which have been circularly permuted relative to the full-length TfR sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.