Bispecific binding proteins and uses thereof

US10457732B2 · kind B2 · utility

Assignee

• MedImmune Limited · US

Inventors

• Srinath Kasturirangan · Gaithersburg, US
• Changshou Gao · Potomac, US
• Godfrey Jonah Anderson Rainey · Gaithersburg, US
• Michelle Morrow · Cambridge, GB
• Claire Louise Dobson · Cambridge, GB
• Stacey Drabic · Gaithersburg, US
• Darren Schofield · Melbourn, GB
• Gianluca Carlesso · Rockville, US
• Kristen POLLIZZI · Gaithersburg, US
• Yariv Mazor · Austin, US
• Michael Oberst · Gaithersburg, US
• Scott Hammond · Gaithersburg, US
• Brian Lobo · Gaithersburg, US
• Prakash Manikwar · Lawrence, US
• Jonathan SEAMAN · Cambridge, GB
• Simon Dovedi · Manchester, GB
• Ronald Herbst · Gaithersburg, US

Key dates

• Filing date: May 5, 2017
• Grant date: Oct 29, 2019
• Expiry date: May 31, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject.