Patent · US Active

Chimeric proteins and methods of regulating gene expression

US10457961B2 · kind B2 · utility

2Cited by

25References

32Claims

0Family size

Assignee

The Board of Trustees of the Leland Stanford Junior University · US

Inventors

Lei S. Qi · Tianjin, CN
P. C. Dave P. Dingal · Stanford, US

Key dates

Filing date	Nov 8, 2017
Grant date	Oct 29, 2019
Priority date	—
Expiry date	Nov 8, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/03
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.