Translocation control for sensing by a nanopore
US10457979B2 · kind B2 · utility
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1References
26Claims
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Key dates
| Filing date | May 14, 2015 |
| Grant date | Oct 29, 2019 |
| Priority date | — |
| Expiry date | Oct 27, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2565/631
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Translocation control for sensing by a nanopore, as well as methods and products related to the same, are provided. Such methods optimize duplex stability to provide high fill rate (of the hybridization sites) but do not prevent rapid dissociation required for high read rates, as well as controlling the translocation of a target molecule for sensing by a nanopore by use of a selective pulsed voltage. Products related to the same include a reporter construct comprising two or more phosphoramidites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.