Patent · US Active

Non-platinum-based anti-cancer compounds for use in targeted chemotherapy

US10463662B2 · kind B2 · utility

3Cited by
0References
15Claims
0Family size

Inventor

Key dates

Filing dateOct 8, 2014
Grant dateNov 5, 2019
Priority date—
Expiry dateOct 8, 2034

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D241/20
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Disclosed herein are non-platinum-based (NPB) anti-cancer compounds useful for targeted chemotherapy, e.g., to generate anti-cancer effects for the treatment of cancer and other disorders while having no or minimal toxicity. The compounds N have the general formula I: (I) wherein A represents an aromatic core; at least one of Ra and Rb is an electron transfer promoter as defined herein, e.g., NH2; and at least one of Rc is a leaving group as defined herein, e.g., halogen; and the remainder of the molecule is as defined herein. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the anti-cancer compounds are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.