Antigen-Specific T cell redirectors

US10463750B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Jonathan Schneck · Silver Spring, US
• Christian Schuetz · Hille, DE

Key dates

• Filing date: Feb 14, 2014
• Grant date: Nov 5, 2019
• Expiry date: Apr 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure describes compositions and methods for selectively recruiting antigen-specific T cells and re-direct them to kill targeted cells, particularly tumor cells. This approach permits selective engagement of specific effector cell populations and, by using nanoparticles, overcomes the geometric limitations associated with previous approaches.