Single use slurrying and chromatography systems
US10463988B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 23, 2011 |
| Grant date | Nov 5, 2019 |
| Priority date | — |
| Expiry date | Dec 27, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/565
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.