Process for the preparation of enantiomerically enriched 3-aminopiperidine

US10464898B2 · kind B2 · utility

Assignee

• Reuter Chemische Apparatebau KG · DE

Inventors

• Karl Reuter · Gundelfingen, DE
• Tobias Wedel · Karlsruhe, DE
• Viktor Meier · Gundelfingen, DE
• Mark Kantor · Freiburg (Elbe), DE
• Vasyl Andrushko · Glückstadt, DE
• Florian Stolz · Glückstadt, DE

Key dates

• Filing date: Feb 19, 2014
• Grant date: Nov 5, 2019
• Expiry date: Feb 19, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/60
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-di-hydrochloride-monohydrate.