Amyloid β(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof

US10464976B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Heinz Hillen · Herbrechtingen, DE
• Andreas Striebinger · Speyer, DE
• Carsten Krantz · Mannheim, DE
• Achim Moeller · Grünstadt, DE
• Reinhold Mueller · Schifferstadt, DE

Key dates

• Filing date: Sep 24, 2015
• Grant date: Nov 5, 2019
• Expiry date: Sep 24, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/4709
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.