Well-defined degradable poly(propylene fumarate) polymers and scalable methods for the synthesis thereof
US10465044B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 18, 2015 |
| Grant date | Nov 5, 2019 |
| Priority date | — |
| Expiry date | Nov 26, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L67/06
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
Method for making poly(propylene fumarate) (PPF) polymer made by ring-opening polymerization of propylene oxide and maleic anhydride in the presence of magnesium ethoxide initiator, wherein PPF is specifically designed for us in 3D manufacturing of medical devices. PPF polymers have a number average molecular weight (Mn) of from about 450 Daltons to about 3400 Daltons; a molecular mass distribution (m) of from 1.0 to 2.0; and contains less than 1% w/w of poly(maleic anhydride-co-propylene oxide) polymer chains particularly. PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.