Methods and reagents for analyzing protein-protein interfaces

US10466249B2 · kind B2 · utility

Assignee

• Revolution Medicines, Inc. · US

Inventors

• Gregory L. Verdine · Boston, US
• M. Nichols · Boston, US
• Sharon Ann Townson · Somerville, US
• Uddhav Kumar Shigdel · Cambridge, US
• Seung-Joo Lee · Goyang-si, KR
• Dylan Talbot Stiles · Cambridge, US
• Neville J. Anthony · Hatfield, US

Key dates

• Filing date: May 9, 2018
• Grant date: Nov 5, 2019
• Expiry date: May 9, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.