Noninvasive 4-D time-resolved dynamic magnetic resonance angiography

US10470676B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• The Trustees of the University of Pennsylvania · US

Inventors

• Danny Wang · Hefei, CN
• Lirong Yan · Los Angeles, US
• Hee Kwon Song · Moorestown, US

Key dates

• Filing date: May 26, 2015
• Grant date: Nov 12, 2019
• Expiry date: Jun 10, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/5614
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for non-contrast enhanced 4D time resolved dynamic magnetic resonance angiography using arterial spin labeling of blood water as an endogenous tracer and a multiphase balanced steady state free precession readout is presented. Imaging can be accelerated with dynamic golden angle radial acquisitions and k-space weighted imaging contrast (KWIC) image reconstruction and it can be used with parallel imaging techniques. Quantitative tracer kinetic models can be formed allowing cerebral blood volume, cerebral blood flow and mean transit time to be estimated. Vascular compliance can also be assessed using 4D dMRA by synchronizing dMRA acquisitions with the systolic and diastolic phases of the cardiac cycle.