In vitro production of red blood cells with proteins comprising sortase recognition motifs
US10471099B2 · kind B2 · utility
15Cited by
5References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 9, 2014 |
| Grant date | Nov 12, 2019 |
| Priority date | — |
| Expiry date | May 9, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.