Ice-based lipid nanoparticle formulation for delivery of mRNA
US10471153B2 · kind B2 · utility
8Cited by
1References
6Claims
0Family size
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Key dates
| Filing date | Nov 10, 2017 |
| Grant date | Nov 12, 2019 |
| Priority date | — |
| Expiry date | Mar 3, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P11/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid. In some embodiments, the present invention provides compositions and methods in which the lipid nanoparticles further comprise helper lipids and PEG-modified lipids. The resulting formulation comprises a high encapsulation percentage for nucleic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.