Activatable fibrin-binding probes
US10471163B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | Sep 12, 2014 |
| Grant date | Nov 12, 2019 |
| Priority date | — |
| Expiry date | May 26, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K7/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods for determining the presence or absence of active thrombus formation using a linear polypeptide that binds fibrin upon cyclization. Also provided are compounds comprising linear polypeptide probes that are cyclized in the presence of protein disulfide isomerase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.