Bicyclic tetrahydrothiazepine derivatives useful for the treatment of neoplastic and/or infectious diseases

US10472341B2 · kind B2 · utility

Assignees

• APEIRON BIOLOGICS AG · AT
• EVOTEC SE · DE

Inventors

• Monika Ermann · Wantage, GB
• Guenther Lametschwandtner · Wien, AT
• Patricia Amouzegh · Abingdon, GB
• Russell Stuart Craft · Groningen, NL
• Thomas Hanke · Veitshöchheim, DE
• Timothy Robin James · Woodstock, GB
• Severine Danielle Jones · Woodstock, GB
• Hans Loibner · Wien, AT
• Pui Leng Loke · Abingdon, GB
• Ina Sternberger · Hamburg, DE
• Anton Stuetz · Mödling, AT
• Roland Wehr · Oettingen, DE
• Mark Whittaker · Felton, GB

Key dates

• Filing date: Feb 29, 2016
• Grant date: Nov 12, 2019
• Expiry date: Feb 29, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/999
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein R1 to R3, X1, X2 and R18 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising such compounds as well as their use as medicaments, especially in methods for the treatment or prevention of a neoplastic and/or infectious disease and in vitro methods.