Potent gamma-secretase modulators

US10472346B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• The Regents of the University of California · US

Inventors

• Steven L. Wagner · Del Mar, US
• William C. Mobley · Palo Alto, US
• Rudolph E. Tanzi · Canton, US
• Graham Johnson · Madison, US
• Ronald N. Buckle · Rensselaer, US
• Nicholas Mayhew · Niskayuna, US
• Robert Jason Herr · Voorheesville, US
• Kevin D. Rynearson · Lemon Grove, US

Key dates

• Filing date: Oct 30, 2015
• Grant date: Nov 12, 2019
• Expiry date: Dec 10, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant Aβ peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L′ is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene.