Biodegradable implant

US10478527B2 · kind B2 · utility

Assignee

• UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG · ZA

Inventors

• Viness Pillay · Sandton, ZA
• Yahya Essop Choonara · Lenasia, ZA
• Pradeep Kumar · Johannesburg, ZA
• Lisa Claire Du Toit · Randburg, ZA
• Poornima Ramburrun · Randburg, ZA

Key dates

• Filing date: Sep 5, 2016
• Grant date: Nov 19, 2019
• Expiry date: Sep 5, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/32
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

This invention relates to biodegradable implants comprising a hydrogel carrier matrix having dispersed therein a multitude of particles, wherein each of the multitude of particles and/or the hydrogel carrier matrix includes an active pharmaceutical ingredient (API) for the treatment of transected peripheral nerve injuries. Each of the multitude of particles and/or the hydrogel carrier matrix includes pristine polymer particles, preferably the pristine polymer particles may be polymethylmethacrylate polymers and derivatives thereof, preferably poly(methacrylic-co-methyl methacrylate) (PMMA). The spheroidal particles may each be formed from an outer shell including a chitosan (CHT) poly(methacrylic-co-methyl methacrylate) (PMMA) polyelectrolyte complex (CHT-PMMA-PEC) and an inner core including crosslinked chitosan having dispersed therein PMMA nanoparticles.