N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amine derivatives as therapeutic compounds
US10479785B2 · kind B2 · utility
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29Claims
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Key dates
| Filing date | Aug 4, 2016 |
| Grant date | Nov 19, 2019 |
| Priority date | — |
| Expiry date | Aug 4, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain, central nervous system, colorectal cancer and leukaemias. The inhibitors have the general structure I:
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