Enhanced production of recombinant CRM197 in E. coli
US10479820B2 · kind B2 · utility
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33Claims
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Key dates
| Filing date | Mar 2, 2015 |
| Grant date | Nov 19, 2019 |
| Priority date | — |
| Expiry date | Feb 10, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N1/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Rediced genome or native K12 strain E. coli bacteria comprising expression vectors encoding a recombinant CRM197 protein and their use in the production of CRM 197 is provided. The CRM 197 protein may be fused to a signal sequence that directs the expressed CRM197 protein to the periplasm of the E. coli host.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.