Patent · US Active

Mikto-arm star polymers for delivery of therapeutic agents

US10485873B2 · kind B2 · utility

0Cited by

4References

21Claims

0Family size

Assignees

International Business Machines Corporation · US
NanoMalaysia Berhad · MY

Inventors

Khairiah H. Badri · Bandar Baru Bangi, MY
Emilia B. A. Malek · Kapar, MY
Siti Mariam B. Mohd Nor · Seri Kembangan, MY
Victoria A. Piunova · Los Gatos, US

Key dates

Filing date	Sep 25, 2017
Grant date	Nov 26, 2019
Priority date	—
Expiry date	Feb 6, 2038

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61Q17/005
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Mikto-arm star polymers were prepared comprising non-charged hydrophilic poly(ethylene oxide) arms and hydrophobic arms comprising a poly(propylene oxide) chain or phytol group. The polymer arms are covalently linked to a hydrophobic crosslinked polyester core formed by ring opening polymerization of a bis-cyclic ester initiated by mono-nucleophilic polymer arm precursors. The mikto-arm star polymers show improved loading capacity for Coenzyme Q10 (CoQ10).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.