Plasma cell cytokine vehicle containing fusion proteins for targeted introduction of siRNA into cells and tissues

US10485879B2 · kind B2 · utility

Assignees

• Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health · US
• Michael R. Simon · US

Inventors

• Bira Arya · Baltimore, US
• Michael R. Simon · Ann Arbor, US

Key dates

• Filing date: Jun 18, 2018
• Grant date: Nov 26, 2019
• Expiry date: Jun 18, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/85
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A fusion molecule is provided that includes one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety. The targeting polypeptide and the nucleic acid binding moiety include specific the amino acid sequences. A fusion molecule is also provided that includes one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety adapted to bind a double-stranded RNA or to a small hairpin RNA. The targeting polypeptide being CCL27 or CCL11 or a fragment thereof.