Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
US10487084B2 · kind B2 · utility
6Cited by
14References
15Claims
0Family size
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Key dates
| Filing date | Aug 14, 2018 |
| Grant date | Nov 26, 2019 |
| Priority date | — |
| Expiry date | Aug 14, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.