Trinucleotide MRNA cap analogs
US10487105B2 · kind B2 · utility
18Cited by
4References
12Claims
0Family size
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Key dates
| Filing date | Oct 19, 2017 |
| Grant date | Nov 26, 2019 |
| Priority date | — |
| Expiry date | Dec 8, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
What is described is a trinucleotide cap analog comprising m7G(5′)p3-N1pN2 for increased efficiency of in vitro transcription of m7G(5′)p3-RNA, wherein m7G is N7-methylguanosine or analog, (5′)p3 is a 5′,5′-triphosphate bridge, and N1 or N2 or both ribonucleotide analogs linked to each other by a phosphate, p, and wherein the trinucleotide cap analog increases the efficiency of in vitro transcription.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.