Asymmetric multispecific antibodies
US10487156B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 20, 2015 |
| Grant date | Nov 26, 2019 |
| Priority date | — |
| Expiry date | Aug 20, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/64
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to multispecific antibodies, for example bispecific antibodies, and methods for the isolation or purification of the same. The antibodies of the invention comprise first and second heavy chain-light chain pairings wherein each pairing comprises a distinct selective recognition site including one or more amino acid residues contributed from the heavy chain and the light chain of the pairing. The first and second selective recognition sites differ by at least one amino acid residue and can be differentially bound by first and second selective recognition agents according to the methods of the invention. Such methods facilitate the production of antibody preparations enriched for multispecific antibodies having the correct functional heavy chain-light chain pairings.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.