Neural circuit probe

US10488391B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Paul K. Hansma · Isla Vista, US
• Kenneth S. Kosik · Belmont, US
• Luke S. K. Theogarajan · Carpinteria, US
• Barney Drake · Truckee, US
• Daniel Bridges · Goleta, US
• Connor Randall · Salida, US
• Kenneth R. Tovar · Portland, US

Key dates

• Filing date: Oct 30, 2015
• Grant date: Nov 26, 2019
• Expiry date: Oct 30, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2015/1006
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A Neural Circuit Probe (NCP) combines a multi-electrode array (MEA) with an automated local probe, wherein the probe is positioned to interact with one or more cells, such as neurons of a neural circuit, grown on or about one or more electrodes of the multi-electrode array. The probe may interact with the cells by electrically recording signals from the multi-electrode array that are assigned to a specific one of the cells. The probe may interact with the cells by locally delivering chemicals to the cells, which transiently and reversibly modulate the electrical behavior of the cells. The probe may interact with the cells by harvesting the cells using a pipette, so that the harvested cells can be sequenced.