Live attenuated viral vaccine created by self-attenuation with species-specific artificial MicroRNA
US10493146B2 · kind B2 · utility
1Cited by
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13Claims
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Key dates
| Filing date | Oct 14, 2015 |
| Grant date | Dec 3, 2019 |
| Priority date | — |
| Expiry date | Oct 14, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16171
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention includes a live attenuated virus and methods of making the same comprising an isolated virus comprising a viral genome that expresses one or more viral antigens; and one or more exogenous species-specific microRNAs inserted into the viral genome and expressed thereby, wherein the species-specific microRNAs are ubiquitously expressed in a viral target species cell but not in a viral propagation cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.