Solution for spray drying comprising hypromellose acetate succinate and method for producing solid dispersion
US10493161B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 12, 2015 |
| Grant date | Dec 3, 2019 |
| Priority date | — |
| Expiry date | Nov 12, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/496
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are provided a solution for spray drying having a high transmittance and markedly reduced generation of undissolved matter; and a method for producing a solid dispersion by using the solution for spray drying so that clogging with the undissolved matter is reduced and dissolution is improved. More specifically, there is provided a solution for spray drying comprising hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more, a solvent, and a drug. There is also provided a method for producing a solid dispersion comprising the step of removing the solvent from the spray drying solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.