Patent · US Active

Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor

US10494370B2 · kind B2 · utility

5Cited by

14References

6Claims

0Family size

Assignee

Bristol-Myers Squibb Company · US

Inventors

Yam B. Poudel · Fremont, US
Liqi He · West Chester, US
Sanjeev Gangwar · Foster City, US
Shoshana L. Posy · Highland Park, US
Prasanna Sivaprakasam · Lawrenceville, US

Key dates

Filing date	Aug 14, 2018
Grant date	Dec 3, 2019
Priority date	—
Expiry date	Aug 14, 2038

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P37/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.