Synthesis of copanlisib and its dihydrochloride salt

US10494372B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Jan-Georg Peters · Solingen, DE
• Philipp Rubenbauer · Bensheim, DE
• Daniel Götz · Düsseldorf, DE
• Danja GROßBACH · Wuppertal, DE
• Franz-Josef Mais · Düsseldorf, DE
• Heiko Schirmer · Solingen, DE
• Juergen Stiehl · Winsen (Aller), DE
• Kai Lovis · Düsseldorf, DE
• Andreas Lender · Wuppertal, DE
• Martin Seyfried · Meilen, CH
• Theodor ZWEIFEL · Zug, CH
• Maurus Marty · Gland, CH
• Günter Weingärtner · Seengen, CH

Key dates

• Filing date: Nov 5, 2015
• Grant date: Dec 3, 2019
• Expiry date: Nov 5, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/088
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.