Neutralizing anti-influenza A antibodies and uses thereof

US10494419B2 · kind B2 · utility

Assignees

• MedImmune Limited · US
• Humabs BioMed SA · CH

Inventors

• Ebony Benjamin · Gaithersburg, US
• Nicole Kallewaard-Lelay · Gaithersburg, US
• Josephine Mary McAuliffe · Gaithersburg, US
• Frances Palmer-Hill · Gaithersburg, US
• Leslie Wachter · Gaithersburg, US
• Andy Yuan · Gaithersburg, US
• Qing Zhu · Mansfield Center, US
• Davide Corti · Bellinzona, CH
• Antonio Lanzavecchia · Bellinzona, CH
• Barbara Guarino · Bellinzona, CH
• Anna DeMarco · Bellinzona, CH

Key dates

• Filing date: Oct 1, 2014
• Grant date: Dec 3, 2019
• Expiry date: Sep 10, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/11
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus. In one embodiment, an antibody or binding fragment according to the invention is capable of binding to and/or neutralizing one or more influenza A virus group 1 subtypes selected from H1, H2, H5, H6, H8, H9, H11, H12, H13, H16 and H17 and variants thereof and one or more influenza A virus group 2 subtype selected from H3, H4, H7, H1, 0, H14 and H15 and variants thereof.