Hyperglycosylated binding polypeptides

US10494439B2 · kind B2 · utility

Assignee

• Genzyme Corporation · US

Inventors

• Clark Pan · Sudbury, US
• Huawei Qiu · Westborough, US
• Pradeep K. Dhal · Westford, US
• Bo Chen · Jinan, CN
• Diego Gianolio · Somerville, US

Key dates

• Filing date: Jun 5, 2017
• Grant date: Dec 3, 2019
• Expiry date: Jun 5, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.