Low-molecular-weight glycosaminoglycan derivative containing terminal 2, 5-anhydrated talose or derivative thereof
US10494452B2 · kind B2 · utility
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Key dates
| Filing date | Dec 20, 2013 |
| Grant date | Dec 3, 2019 |
| Priority date | — |
| Expiry date | May 24, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H5/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A low-molecular-weight fucosylated glycosaminoglycan (aTFG) containing 2,5-anhydrated talose, alditol, glycosylamine or N-substituted glycosylamine monosaccharide composition thereof, preparation method thereof, pharmaceutical compositions containing the aTFG, and use thereof for preventing and/or treating thrombotic diseases are provided. The aTFG has potent anticoagulant activity targeting at intrinsic coagulation factor Xase, and inhibiting thrombogenesis, and therefore can be used as drugs for preventing and/or treating cardiovascular and cerebrovascular diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.