Adeno-associated virus virions with variant capsid and methods of use thereof
US10494612B2 · kind B2 · utility
3Cited by
32References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2016 |
| Grant date | Dec 3, 2019 |
| Priority date | — |
| Expiry date | Sep 27, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/855
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.