Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease
US10500227B2 · kind B2 · utility
1Cited by
5References
6Claims
0Family size
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Key dates
| Filing date | Dec 3, 2015 |
| Grant date | Dec 10, 2019 |
| Priority date | — |
| Expiry date | Dec 3, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1278
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Echogenic liposomes (ELIP) formulated with an at least partially pegylated phospholipid bi-layer shell, encapsulated nitric oxide, and encapsulated perfluorocarbon of the formula CxFy in a ratio of about 1:1 by volume, wherein X is greater than or equal to 3, are disclosed, along with methods for treating a patients suffering from cardiovascular disease by administering the ELIP at a site remote from the target diseased section, monitoring presence of the ELIP at the target diseased section, and administering ultrasound upon detection of presence such that bioactive NO is released at the target diseased section.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.