DNA vaccines and methods for the prevention of transplantation rejection
US10500258B2 · kind B2 · utility
2Cited by
1References
16Claims
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Key dates
| Filing date | Jun 3, 2016 |
| Grant date | Dec 10, 2019 |
| Priority date | — |
| Expiry date | Apr 15, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/577
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.