Substituted nitrogen containing compounds

US10501449B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Navnath Dnyanoba Yadav · Bengaluru, IN
• Rajeev S. Bhide · Princeton Junction, US
• Rajesh Onkardas Bora · Bengaluru, IN
• Prashantha Gunaga · Savanuru, IN
• Manoranjan Panda · Survanagiri, IN
• Eldon Scott Priestley · Yardley, US
• Jeremy Richter · Ewing, US

Key dates

• Filing date: May 31, 2018
• Grant date: Dec 10, 2019
• Expiry date: May 31, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.