HPK1 inhibitors and methods of using same
US10501474B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | Jun 23, 2016 |
| Grant date | Dec 10, 2019 |
| Priority date | — |
| Expiry date | Jun 23, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X1; X2, and X3 is S and the other two are each independently CR, wherein R and all other variables are as defined herein. The compounds are shown to inhibit HPK1 kinase activity and to have in vivo antitumor activity. The compounds can be effectively combined with pharmaceutically acceptable carriers and also with other immunomodulatory approaches, such as checkpoint inhibition or inhibitors of tryptophan oxidation. Formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.