Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use

US10501558B2 · kind B2 · utility

Assignee

• Sutro Biopharma, Inc. · US

Inventors

• Christopher D. Thanos · Tiburon, US
• Leslie McEvoy · Mountain View, US
• Gang Yin · South San Francisco, US
• Kalyani Penta · Palo Alto, US
• Ramesh Baliga · Redwood City, US
• Sunil Bajad · Fremont, US
• Sonia Pollitt · San Mateo, US
• Chris Murray · Soquel, US
• Alex Steiner · San Francisco, US
• Avinash Gill · Emeryville, US

Key dates

• Filing date: Jun 23, 2017
• Grant date: Dec 10, 2019
• Expiry date: Jun 23, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are modified Fc proteins comprising non-natural amino acid residues at site-specific positions, conjugates of the modified Fc proteins for therapy or diagnosis, compositions comprising the modified Fc proteins and conjugates thereof, methods of their production and methods of their use. The modified Fc proteins and conjugates are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.