Patent · US Active

Recombinant baculovirus and method for using the same for preparing recombinant adeno-associated virus vector

US10501758B2 · kind B2 · utility

2Cited by

1References

12Claims

0Family size

Assignee

WUHAN INSTITUTE OF PHYSICS AND MATHEMATICS, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Yang-Chang Wu
Fuqiang XU · Shanghai, CN
Xiaobin He · Los Angeles, US

Key dates

Filing date	Jan 31, 2018
Grant date	Dec 10, 2019
Priority date	—
Expiry date	Jan 31, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2800/22
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A recombinant baculovirus, including: an adeno-associated virus Rep gene, an adeno-associated virus Cap gene, and an recombinant adeno-associated virus genome ITR-GOI (gene of interest) flanked by rAAV inverted terminal repeats (ITR). The ITR-GOI includes a 5′ terminal nucleic acid fragment and a 3′ terminal nucleic acid fragment. The ITR-GOI is linked to an expression cassette of the Cap gene and an expression cassette of the Rep gene through the 5′ terminal nucleic acid fragment and the 3′ terminal nucleic acid fragment, respectively.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.