Identification of tumor-protective epitopes for the treatment of cancers

US10501801B2 · kind B2 · utility

Assignee

• UNIVERSITY OF CONNECTICUT · US

Inventors

• Pramod K. Srivastava · Avon, US
• Ion Mandoiu · Storrs, US
• Fei Fan DUAN · Hsinchu, TW

Key dates

• Filing date: Sep 27, 2013
• Grant date: Dec 10, 2019
• Expiry date: Oct 21, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are methods of identifying tumor-specific epitopes from the cancer tissue DNA of cancer patients using both DNA sequencing and bioinformatics techniques. The identification of tumor-specific epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a novel index called the Differential Agretopic Index (DAI) for the epitope which allows prediction of whether immunization with a particular epitope will be protective against the tumor. Pharmaceutical compositions and methods of administration are also included.