Identification of antigen- or ligand-specific binding proteins
US10502745B2 · kind B2 · utility
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53References
18Claims
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Key dates
| Filing date | Jan 27, 2017 |
| Grant date | Dec 10, 2019 |
| Priority date | — |
| Expiry date | Nov 20, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B30/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.
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