Regenerative tissue grafts and methods of making same

US10507187B2 · kind B2 · utility

Assignees

• The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. · US
• THE UNITED STATES GOVERNMENT, AS REPRESENTED BY THE SECRETARY OF THE ARMY, U.S.A. · US
• The Government of the United States of America as represented by the Secretary of the Deptartment of Health and Human Services · US

Inventors

• Wesley M. Jackson · Albany, US
• Leon J. Nesti · Silver Spring, US
• Rocky S. Tuan · Pittsburgh, US

Key dates

• Filing date: Feb 12, 2014
• Grant date: Dec 17, 2019
• Expiry date: Feb 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.