Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
US10508115B2 · kind B2 · utility
3Cited by
14References
19Claims
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Key dates
| Filing date | Aug 14, 2018 |
| Grant date | Dec 17, 2019 |
| Priority date | — |
| Expiry date | Aug 14, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6841
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.