Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway

US10508129B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Zhijian Chen · Dallas, US
• Lijun Sun · Harvard, US
• Jiaxi WU · Dallas, US
• Heping Shi · Dallas, US
• Chuo Chen · Dallas, US

Key dates

• Filing date: May 7, 2019
• Grant date: Dec 17, 2019
• Expiry date: May 7, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.