Methods for identifying selective binding pairs
US10508273B2 · kind B2 · utility
8Cited by
60References
19Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 24, 2019 |
| Grant date | Dec 17, 2019 |
| Priority date | — |
| Expiry date | Apr 24, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure methods for identifying binding partners using cell surface display libraries, where the cells of the library display engineered peptides on their cell surfaces for identification of peptides that bind to targets of interest. The engineered peptides are preferably expressed in the cells under conditions that provide both secretion and display of the engineered peptides on the cell surfaces, thus providing access of the engineered peptides to identify potential binding pairs. The cell libraries cab be engineered using an automated editing system that provides for one or more targeted edits per cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.